5-bromo-1H-pyrazoio[3,4-b]pyridine
5-Bromo-1H-pyrazolo[3,4-b]pyridine
CAS: 875781-17-2
Molecular Formula: C6H4BrN3
5-bromo-1H-pyrazoio[3,4-b]pyridine - Names and Identifiers
| Name | 5-Bromo-1H-pyrazolo[3,4-b]pyridine |
| Synonyms | EOS-61661 4-b]pyridine 5-broMo-1H-pyrazolo[3 7-Aza-5-bromo-1H-indole 5-Bromopyrazolo[3,4-b]pyridine 5-Bromo-1H-Pyrazo[3,4-B]Pyridine 5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE 5-Bromo-1H-pyrazolo[3,4-b]pyridine 5-bromo-1H-pyrazoio[3,4-b]pyridine 5-methyl-1H-pyrazolo[3,4-b]pyridine 1H-Pyrazolo[3,4-b]pyridine, 5-bromo- 1H-Pyrazolo[3,4-b]pyridine, 5-broMo- 2H-pyrazolo[3,4-b]pyridine, 5-methyl- |
| CAS | 875781-17-2 |
| EINECS | 807-974-3 |
| InChI | InChI=1/C7H7N3/c1-5-2-6-4-9-10-7(6)8-3-5/h2-4H,1H3,(H,8,9,10) |
| InChIKey | BASYLPMLKGQZOG-UHFFFAOYSA-N |
5-bromo-1H-pyrazoio[3,4-b]pyridine - Physico-chemical Properties
| Molecular Formula | C6H4BrN3 |
| Molar Mass | 198.02 |
| Density | 1.894±0.06 g/cm3(Predicted) |
| Melting Point | 198.0 to 202.0 °C |
| Boling Point | 329.0±22.0 °C(Predicted) |
| Flash Point | 147.6°C |
| Vapor Presure | 0.00148mmHg at 25°C |
| Appearance | Yellow crystal |
| pKa | 8.66±0.40(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.68 |
| MDL | MFCD05663982 |
5-bromo-1H-pyrazoio[3,4-b]pyridine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
5-bromo-1H-pyrazoio[3,4-b]pyridine - Reference Information
| use | 5-bromo-1H-pyrazolo [3,4-B] pyridine Chinese alias 5-bromopyrazolo [3,4-b] pyridine, pyrazolo [3,4-B] pyridine compound is a very important kind of thick heterocyclic ring, due to its specific physiological activity and structural similarity with indole, azafindole, etc., it has aroused widespread interest and is a very important type of dense heterocyclic compound. They have good curative effects in the prevention and treatment of gram-negative and positive bacteria, tumors and cancers, asthma, neurological diseases, osteoporosis and Alzheimer's disease, and have a wide range of applications in the fields of pharmaceuticals, pesticides and dyes. |
| Preparation | When synthesizing pyrazolopyridine compounds with pyridine ring as the parent ring, hydrazine or substituted hydrazine is generally used to close the ring. If 3, 6-dichloro-2-pyridine formaldehyde reacts with hydrazine to undergo bromination reaction, 5-bromo-1H-pyrazolo [3,4-B] pyridine can be prepared. In addition, 5-bromo-1H-pyrazolo [3,4-b] pyridine can be synthesized from 2-fluoro -5-bromopyridine -3-formaldehyde in a yield of about 46%; or 5-bromo-1H-pyrazolo [3,4-b] pyridine can be synthesized from 3-aminopyrazole and 2-bromomalondialdehyde in a yield of about 11%; in this paper, 5-bromo-2-hydrazinylpyridine hydrochloride is used as the starting material to prepare 5-bromo-1H-pyrazolo [3,4-B] pyridine by intramolecular ring-forming reaction. The preparation reaction formula is as follows. Fig. 1 5-bromo-1H-pyrazolo [3,4-B] pyridine preparation reaction formula |
Last Update：2024-04-09 20:49:11
![5-bromo-1H-pyrazoio[3,4-b]pyridine](http://res.chembk.com/assets/images/structure/875781-17-2.gif)
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View History
5-bromo-1H-pyrazoio[3,4-b]pyridine
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[2-[[4-[(2-cyano-4-nitrophenyl)azo]phenyl]ethylamino]ethyl]trimethylammonium methyl sulphate
1-Norbornanecarboxylicacid
NONYLPHENYL-POLYETHYLENE GLYCOL
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qyc5
phosphorodichloridousacid,phenylester
[2-[[4-[(2-cyano-4-nitrophenyl)azo]phenyl]ethylamino]ethyl]trimethylammonium methyl sulphate
1-Norbornanecarboxylicacid
NONYLPHENYL-POLYETHYLENE GLYCOL
桦木醇
2,2'-偶氮二异丁基脒二盐酸盐
冰染偶合组分 25
2-(4-溴-1H-吲哚-3-基)乙醇